Brain Trauma Blueprint - State of the Science Summit

Brain Trauma Blueprint

The Brain Trauma Blueprint is a roadmap to advance precision diagnostics and therapeutics for survivors of brain trauma by outlining research endeavors and fostering collaboration across the broader stakeholder community. One pivotal component of the Blueprint Process is to convene key stakeholders at a State of the Science Summit, which aims to survey the current scientific knowledge, identify knowledge gaps and consider new scientific and clinical models and actionable research priorities that will inform funding efforts and accelerate the development of a new generation of precision diagnostics and targeted therapeutics. By fostering collaboration across the broader stakeholder community, we will enable translational research gaps to be bridged and achieve solutions sooner for those suffering from trauma-related brain disorders.

The need is significant.

  • Most people will experience at least one traumatic event in their lifetime.
  • Estimates suggest approximately 24.4 million Americans suffer from PTSD.
  • An average of 2.8 million Americans will experience a traumatic brain injury every year.
  • Recent research suggests that even a single concussive event may cause neurocognitive changes in individuals at any point post-injury.
  • The morbidity and mortality of PTSD and chronic neuropsychiatric effects of TBI are further magnified by the substantial disruptions in family, workplace, and societal contexts, all contributing to the enormous clinical, social, and financial burden of ineffectively treated trauma-related brain disorders.

The resolutions are few.

  • There is a paucity of therapeutic options for these conditions.
  • The developmental pipeline is meager compared with other prevalent CNS disorders.
  • There are no objective diagnostics for PTSD or for the chronic neuropsychiatric effects of TBI.
  • These disorders also lack validated treatment response and prognostic biomarkers and objective outcome measures.
  • This situation is related to, and exacerbated by, the limited understanding of the biological underpinnings of these disorders.

Together, we will empower all stakeholders to be informed and strategic architects through the Translational Science Brain Trauma Blueprint.

Latest News & Publications

Traumatic Brain Injury: A Framework to Advance Biomarker Development for Diagnosis, Outcome Prediction, and Treatment

Published in the Journal of Neurotrauma, the article focuses on the pressing need for multi-modal biomarkers for traumatic brain injury to guide the development of diagnostics and personalized, targeted therapies.

Traumatic Brain Injury: Strategies for Implementing Diagnosis and Treatment Guidelines

Published in the Journal of Neurotrauma, the article reviews factors that impact adoption and implementation of best practices for the management of traumatic brain injury (TBI). It also examines enablers of implementation and strategies for mitigating the barriers to optimal uptake.

Cohen Veterans Bioscience, Stanford Brain Performance Center, and Brain Trauma Foundation Join Forces to Advance Precision Medicine for TBI

Cohen Veterans Bioscience, Stanford Brain Performance Center, and the Brain Trauma Foundation announced a collaboration aimed at transforming the treatment recommendations and guidelines for mild traumatic brain injury (TBI) (inclusive of concussion) and advancing the field more broadly toward a precision medicine approach.

Traumatic Brain Injury: Advancing Preclinical Science

The coauthored review discusses the state of preclinical research in traumatic brain injury (TBI), how preclinical models contribute to the success and failure of clinical solutions for TBI, and considerations for their improvement to aid translational science.

In TBI, Identifying Population Differences is Critical to Improving Lives

Identifying how factors like age, race, and co-existing conditions influence TBI outcomes across populations could inform standardized precision solutions

Traumatic Brain Injury: A New Roadmap Outlining Opportunities, Barriers, and Recommendations for Advancing Treatment Solutions

Announcing the launch of a National TBI Precision Solutions Research Roadmap, the first in a series of publications resulting from the Brain Trauma Blueprint framework program.